Domstal Dosage and Side Effects
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Domstal Dosage and Side Effects

Domstal Dosage and side effects Domstal active ingredients- Domperidone and Cinnarizine . Domstal Used for • Treating motion sickness (nausea and/ or vomiting), • Treating feeling of feeling heavy after meal, • Treat heartburn, stomach discomfort and acidity, because of food ingredients flowing back to the food pipe from the stomach.

Domstal Dosage and side effects

Domstal active ingredients- Domperidone and Cinnarizine .

Domstal Used for

• Treating motion sickness (nausea and/ or vomiting),

• Treating feeling of feeling heavy after meal,

• Treat heartburn, stomach discomfort and acidity, because of food ingredients flowing back to the food pipe from the stomach.

Domstal may also be used for other ailments not listed above.

Dosage

Oral

Motion sickness

Adult: a Domstal administered 1-2 hours prior to travel and 1 tablet every six hrs at some stage in voyage if essential.

Pharmacokinetics

Cinnarizine has Ca channel obstructing action discriminative for arterial even muscles. It has various antihistamine actions. Cinnarizine works as a labyrinthine tranquilizer. It also develops micro flow by decreasing ischaemia- stimulated blood thickness.

Domperidone is a secondary dopamine-receptor obstructer. It enhances equally the lower oesophageal sphincter pressure and the oesophageal peristalsis. It in addition amplifies peristalsis and gastric motility, and boosts gastro duodenal management, thus assisting gastric discharging and declining diminutive bowel transfer moment.

Domstal Adverse Reactions

Domstal Side Effects

Additional pyramidal signs occasionally connected with acute depression. Headache, Drowsiness, unsteadiness, GI upsets.

Infrequently skin allergic reactions, condensed resp depression, dry mouth, blurred vision, problem in urinating and urinary retention, diarrhea ,constipation , fatigue and amplified gastric reflux.

Hypolipidaemic effect, galactorrhoea, skin rash, additional pyramidal reactions, gynaecomastia, reduced libido, lassitude, itch.

Potentially fatal: arrhythmias and heart attack, Convulsions, dysrrhythmias in subjects with hypokalaemia or CVS ailment, subjects on cancer chemotherapy. Hypertensive crisis convulsions, in subjects with phaeochromocytoma.

Consult a doctor in case any of these side effects occur and/ or become persistent or troublesome.

These may not be the complete list of Domstal side effects, for additional information consult with your health care provider.

Special Precautions

Hypotension; May weaken capability to drive a vehicle or manage heavy machinery.

Pheochromocytoma; renal damage or hepatic injury; danger of cardiac arrhythmias and hypokalaemia if used IV. Aged, pregnancy and lactation

Other Drug Interactions

CNS depressant action of cinnarizine is improved with alcohol. Domperidone decreases combination of digoxin. It enhances action of paracetamol, aspirin, and diazepam. Amplifies CNS drugs for depression by phenothiazine.

Opioids and antimuscarinic agents antagonize GI effects. Extends uxamethonium-stimulated neuromuscular obstruction.

Other Interactions

Food Interactions

Deferred concentration but elevated bioavailability owing to condensed first-pass breakdown in gut wall.

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Comments (1)
My wife age 69yrs (retired Joint Director - Road research Lab- Govt. of Gujarat, INDIA)and weighing 78kgs having problem of Irritating Bowl, stomach heaviness after food and acidity. Her digestion is very slow and practically no gas outage from stomach from top or bottom sides. resulting in frequent vomiting sensations or uneasy stomach. She is mild diabetic and BP patient too along with Sleeplessness but all in control with good administration of medicines. Her GI expert has prescribed Domstal (1-1-1) before breakfast or meals, Pentocide 40mg 1-0-0 before B/fast and 0-0-1 Prothiadin 50mg (with Lonazep 0.5mg by Physician)at night prior to sleep. She is taking Domstal since last 20 years but her digestion problem still persist. My question is whether Domstal has any long term side effects on muscles performance and swelling on foot. Also her feeling of tiredness, drymouth and exhaustive dreams at night are due to side effects on long term Domstal administration. Sr, if desired by you, I may give full prescription of all medicines she is taking and expect you to help me to relieve my wife from varied digestion problems and other related uncomfortable conditions as described above.Kindly help at earliest. Thanking you, Piyush D Joshi. (Mobile) +91-940-927-9733 Landline)+91-265-239-6584
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