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Zitotec (Misoprostol) Tablets

Pharmacokinetics Zitotec (Misoprostol) is broadly absorbed and experiences quick de-esterification to its liberated acid, which is accountable for its mechanism of action and, contrasting the parent composite, is measurable in plasma.

Zitotec (Misoprostol) Tablets

Active ingredients- Each uncoated Zitotec tablet contains misoprostol 25 mcg, 100 mcg or 200 mcg.

Clinical Pharmacology

Zitotec (Misoprostol) is an orally used active artificial prostaglandin E, analogue.

Mechanism of Action

Prostaglandin E, imbibes myomeirial contractions by reacting with definite receptors on myometrial groups. This combination results an alteration in calcium absorption, thereby instigating muscle tightening. By working together with prostaglandin receptors, Zitotec (Misoprostol) imbibes the cervix to mitigate and uterus to tighten, ensuing in the eviction of the uterine contents.

Pharmacokinetics

Zitotec (Misoprostol) is broadly absorbed and experiences quick de-esterification to its liberated acid, which is accountable for its mechanism of action and, contrasting the parent composite, is measurable in plasma. The beta side chain experiences omega -oxidation and the alpha side chain experiences beta oxidation trailed by decrease of the ketone to provide prostaglandin F analogues.

The substance is a lipophilic methyl ester pro-drug and is voluntarily broken down to its organically active structure. In regular patients, Zitotec (Misoprostol) is quickly absorbed by the body after oral intake with a Tmax of misoprostol acid of 12 ± 3 minutes and a fatal half-life of 20-40 minutes.

After single use of Zitotec (Misoprostol), a linear connection with dose over and above the range of 200-400 mcg has been confirmed. No accretion of misoprostol acid was observed in numerous dose researches. Stable state plasma levels are attained within two days.

Utmost plasma absorption of misoprostol acid is reduced when the drug is administered with food and total accessibility of misoprostol acid is decreased by the intake of concomitant antacid. The serum protein fastening of misoprostol acid is lower than 90% and this binding is autonomous of the absorption of misoprostol.

After oral intake of radiolabeled misoprostol, about 80% of perceived radioactivity emerges in urine.

In patients over 64, the AUC for misoprostol acid is amplified. No schedule quantity alteration is suggested in elderly patients or patients suffering from renal ailments, but uses may need to be decreased if the normal dose is not accepted.

After vaginal uses, the plasma absorption steadily amplified, attaining highest levels after 70-80 minutes and gradually reduced with noticeable levels abter about 6 hours. Vaginal misoprostol was used for longer than oral misoprostol and thus its length of spurring of the uterus crosses that of oral misoprostol.

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