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Methycobal Tablets (Mecobalamin 500 Mcg)

Methycobal Tablets (Mecobalamin 500 mcg) Each Methycobal sugar coated Tablet contains: Mecobalamin 500 mcg (Appropriate overages added) Color: Titanium Dioxide Methycobal is a mecobalamin drug, a co-enzyme of Vitamin B that transpires in the blood and the cerebrospinal fluid. It is utilized by the nerve tissue more broadly than other homologues of vitamin B12. Indications Methycobal Tablets are administered for treating peripheral neuropathies.

Methycobal Tablets (Mecobalamin 500 mcg)

Each Methycobal sugar coated Tablet contains: Mecobalamin 500 mcg (Appropriate overages added) Color: Titanium Dioxide

Methycobal is a mecobalamin drug, a co-enzyme of Vitamin B that transpires in the blood and the cerebrospinal fluid. It is utilized by the nerve tissue more broadly than other homologues of vitamin B12.

Indications

Methycobal Tablets are administered for treating peripheral neuropathies.

Pharmacology:

Pharmacodynamics

Methycobal Tablets (Mecobalamin) is a form of endogenous coenzyme B12, which plays a significant role in the separation of methionine from homocysteine. It also encourages the metabolic pathways concerned in the production of nucleic acids, proteins and lipids during its role in the transmethylation reaction; it thus aids in the fixing of injured nerve tissues. It is better carried to the nerves as compared to cyanocobalamin, as exposed by animal studies and is in charge for the production of nucleic acids and proteins in the nerves. It has been seen in trials on neural tissue that mecobalamin is occupied in the production of thymidine from deoxyuridine, encouragement of deposited folic acid utilization and nucleic acid metabolism.

Methycobal Tablets (Mecobalamin has also been seen to encourage axonal transport and regeneration. It regularizes axonal transport in sciatic nerve cells from rats with streptozocin induced diabetes mellitus. In addition, it also demonstrates inhibitory effects on nerve degeneration in animal models of neuropathies.

It supports synthesis of lecithin, the main ingredient of medullary sheath lipids. It also reinstates deferred synaptic transmission and reduced neurotransmission to normal.

In addition, it has been shown to restore end plate possible stimulation early by escalating nerve fiber excitability in the compressed sciatic nerve in rats. It also normalizes reduced brain tissue levels of acetylcholine in rats administered a choline deficient diet.

Reports from a range of clinical studies advocate that mecobalamin is advantageous in patients with peripheral neuropathies in doses of 1500 mcg, given in separated doses.

Pharmacokinetics

Serum B12 concentration was administered in healthy, adult male volunteers, given an oral dose on a daily basis of 1500 mcg of mecobalamin for a period of 12 successive weeks. Serum total B12 concentration was also administered in the same group of volunteers for 4 weeks instantly after last dose. The serum concentration amplified for the first 4 weeks after dosage, reaching a value two times as high as the original concentration. Thereafter, there was a steady boost, which attained a maximum of about 2.B times the original value at the 12th week of administration. The serum concentration declined after 12 weeks but was still roughly 1.6 times the level at 4 weeks after the last dosing.

 

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Comments (1)

Valuable medicine information well presented. voted up.

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