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Domstal Dosage and Side Effects

Domstal Dosage and side effects Domstal active ingredients- Domperidone and Cinnarizine . Domstal Used for • Treating motion sickness (nausea and/ or vomiting), • Treating feeling of feeling heavy after meal, • Treat heartburn, stomach discomfort and acidity, because of food ingredients flowing back to the food pipe from the stomach.

Domstal Dosage and side effects

Domstal active ingredients- Domperidone and Cinnarizine .

Domstal Used for

• Treating motion sickness (nausea and/ or vomiting),

• Treating feeling of feeling heavy after meal,

• Treat heartburn, stomach discomfort and acidity, because of food ingredients flowing back to the food pipe from the stomach.

Domstal may also be used for other ailments not listed above.

Dosage

Oral

Motion sickness

Adult: a Domstal administered 1-2 hours prior to travel and 1 tablet every six hrs at some stage in voyage if essential.

Pharmacokinetics

Cinnarizine has Ca channel obstructing action discriminative for arterial even muscles. It has various antihistamine actions. Cinnarizine works as a labyrinthine tranquilizer. It also develops micro flow by decreasing ischaemia- stimulated blood thickness.

Domperidone is a secondary dopamine-receptor obstructer. It enhances equally the lower oesophageal sphincter pressure and the oesophageal peristalsis. It in addition amplifies peristalsis and gastric motility, and boosts gastro duodenal management, thus assisting gastric discharging and declining diminutive bowel transfer moment.

Domstal Adverse Reactions

Domstal Side Effects

Additional pyramidal signs occasionally connected with acute depression. Headache, Drowsiness, unsteadiness, GI upsets.

Infrequently skin allergic reactions, condensed resp depression, dry mouth, blurred vision, problem in urinating and urinary retention, diarrhea ,constipation , fatigue and amplified gastric reflux.

Hypolipidaemic effect, galactorrhoea, skin rash, additional pyramidal reactions, gynaecomastia, reduced libido, lassitude, itch.

Potentially fatal: arrhythmias and heart attack, Convulsions, dysrrhythmias in subjects with hypokalaemia or CVS ailment, subjects on cancer chemotherapy. Hypertensive crisis convulsions, in subjects with phaeochromocytoma.

Consult a doctor in case any of these side effects occur and/ or become persistent or troublesome.

These may not be the complete list of Domstal side effects, for additional information consult with your health care provider.

Special Precautions

Hypotension; May weaken capability to drive a vehicle or manage heavy machinery.

Pheochromocytoma; renal damage or hepatic injury; danger of cardiac arrhythmias and hypokalaemia if used IV. Aged, pregnancy and lactation

Other Drug Interactions

CNS depressant action of cinnarizine is improved with alcohol. Domperidone decreases combination of digoxin. It enhances action of paracetamol, aspirin, and diazepam. Amplifies CNS drugs for depression by phenothiazine.

Opioids and antimuscarinic agents antagonize GI effects. Extends uxamethonium-stimulated neuromuscular obstruction.

Other Interactions

Food Interactions

Deferred concentration but elevated bioavailability owing to condensed first-pass breakdown in gut wall.

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